|
KMID : 0361420020260030279
|
|
Journal of Korean Academy of Rehabilitation Medicine
2002 Volume.26 No. 3 p.279 ~ p.284
|
|
|
Comparing the Effect of Two Doses of Botulinum Toxin A (Dysport®) for Treatment of Calf Muscle in Spastic Cerebral Palsy
|
|
방문석/Moon Suk Bang
이시욱/박진우/김상준/Shi Uk Lee/Jin Woo Park/Sang Jun Kim
|
|
|
Abstract
|
|
|
Objective: To determine the effective and safe dose of Dysport® (one of the commercial botulinum toxins) for relieving the spasticity of calf muscle in cerebral palsy.
Method: Twenty spastic cerebral palsy children (34 limbs) were randomly assigned to a high dose (HD; 16 Unit/㎏/limb) injection group and low dose (LD; 8 Unit/㎏/limb) injection group. Locomotor rating scale (LRS) and parameters of 3
dimensional
gait analysis including ankle dorsiflexion angle at stance phase (MADA), maximal dynamic gastrocnemius (MDGL) and soleus length (MDSL) were assessed before, 4 weeks after, and 12 weeks after injection.
Results: Mean LRS, MADAs, MDGLs and MDSLs were significantly increased both 4 and 12 weeks after injection in HD group. In LD group, LRS, MADAs, MDGLs and MDSLs showed some improvement but they were statistically insignificant. The high dose
had
no adverse effect except the mild and transient weakness, which was tolerable to the cerebral palsy patients.
Conclusion: The present study demonstrated the high dose injection of Dysport® was more effective than the low dose injection to relieve the spasticity of calf muscle in cerebral palsy.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|